If you're looking to get off antidepressants and try CBD as an alternative, we've got the information to help you start making the right choice for you. medications are known to interact with cannabis. Cymbalta (duloxetine) · Fish Oil (omega-3 polyunsaturated fatty acids) · Flexeril (cyclobenzaprine). Before looking at possible interactions of marijuana and Wellbutrin, what is it? Wellbutrin is the brand name of a drug called bupropion, and it's used to treat.