Compare Differin vs Tretinoin Topical head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Differin rated /10 vs Tretinoin . solution and tretinoin % gel, both topical treatments for acne, in a once- daily dosage regimen . ficant differences between groups were observed in the. ratio to receive, once daily, adapalene % gel or tretinoin % cream. . 95% in order to detect a difference between treatment arms. Forgotten your password? Because of this, it isn't always the best option. You'll just notice side effect like dryness and peeling become less and less over time. Retinol products can improve the skin, and the good news is that they are generally fairly gentle. In addition to Bteween, some good alternatives are Epiduo and Retin-A. Because acne is a skin condition that causes glands to produce too much oil, there's a natural connection. Differfnce doesn't mean they don't work as well over time; they do.