In my experience, having been prescribed both at the same time, no, I experienced a complete cancelled out effect of both medications. Wellbutrin was . A Major Drug Interaction exists between Adderall and Wellbutrin. alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous Do not stop using any medications without first talking to your doctor. Wellbutrin is not an ADHD medication, but rather an antidepressant used off label to treat prescribed in conjunction with a stimulant medication like Vyvanse or Adderall XR. If side effects are bothersome, or do not go away, talk to your doctor. It can impact the dosage required for CYP2B6 inducers including ritonavir. If the combination does occur, it starts with low doses, and the patient is closely monitored to see if there is an adverse reaction. Mention the brand, dose, and period of time that you used the medication or treatment. More than 20 years later, a pharmaceutical executive named Roger Griggs thought to revisit the now largely forgotten Obetrol. However, the risk of combining these two drugs outweighs the benefits. Open in a separate window. It is important to talk to your doctor if you are pregnant wllbutrin planning to become pregnant.