Bupropion is an effective antidepressant with efficacy comparable to selective . Bupropion was as effective as desipramine for bipolar depression, but was. Overall, the drug is extremely effective but please keep in mind no antidepressant is a "happy" pill that will all of the Related Reading: wellbutrin | depression. Three reasons clinicians skip over bupropion. One could say that bupropion is at least almost as good at treating anxious depression as. Insane migraine depressiom, stomach pain nausea, ear pain, ringing in the ears, vision problems, vertigo, suicidal thoughts. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications si medical conditions. The exact way Wellbutrin works to treat these conditions is unknown. I have progressive multiple sclerosis and depression is a huge problem with me along with weight gain, motivation etc This was the worst thing to take if you have anxiety associated with your depression. Hard, cystic pimples with a few pustules and lots of blackheads thrown in. Miscellaneous antidepressants. I have never been so sick from taking any drug like I was from this drug.