Wellbutrin, or bupropion, is a drug that is mainly used to treat depression. This article will look at how Wellbutrin is used, how it works, its side effects, and any important warnings. Most antidepressants are selective serotonin reuptake inhibitor (SSRI). Bupropion was originally classified as an "atypical" antidepressant because it does not exert the same effects as the classical antidepressants. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin. The risk or severity of adverse effects can be increased when Bupropion is combined with Diphenadione. Fryer JD, Lukas RJ: Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine. Bupropion may decrease the excretion rate of N-methylnicotinamide which could result in a higher serum level. Physicians Total Care Inc. The risk or severity of adverse effects can be increased when Bupropion is combined with Clomethiazole. Atazanavir may decrease the excretion rate of Bupropion which could result in a higher serum level. Bupropion may increase the central nervous system depressant CNS depressant activities of Dimetindene.